Endocrine Abstracts

C-reactive protein (CRP) is a marker of inflammatory processes which predicts vascular disease, and is raised in the circulation of women with PCOS. Metformin can be used to reduce insulin resistance in women with PCOS, leading to improved ovarian function and circulating lipid profiles. The aim of this study was to determine the effect of protracted metformin treatment on circulating CRP in women with PCOS.Methods: CRP was assessed in women with PCOS (n...

Recent data suggests that oestrogen(E)-responsive somatostatin neurones are involved in the generation of the ovine GnRH surge. Specifically, somatostatin neurones in the hypothalamus are activated (as assessed by nuclear fos) and mRNA levels are elevated in the early stages of the surge induction process. In addition, somatostatin fibres have been visualised in close apposition to hypothalamic GnRH neurones, which may indicate direct neural connection between GnRH and somatos...

BackgroundTransdermally absorbed alcohol-based testosterone gel has presented an alternative method of gonadal therapy. This study was designed to investigate the clinical effectiveness of this alternative hormonal replacement.Method97 men requiring testosterone replacement therapy for primary (21%) or secondary (79%) hypogonadism were recruited. The subjects underwent physical examination, psychological asse...

Introduction: Hyperparathyroidism (HPT) during pregnancy is rare but requires a specific approach for its diagnosis HPT is associated with a high incidence of associated maternal, fetal and neonatal complications, including miscarriage (3,5x-fold higher than expected), IUGR, prematurity and pre-eclampsia(1,2,3). The severity of complications is proportional to degree of maternal calcium level.Case report: We report the c...

Several studies suggest that mortality rates due to cardiovascular disease (CVD) are increased in patients with hypopituitarism. We retrospectively assessed the prevalence of known diabetes, treated hypertension and dyslipidemia, known risk factors for cardiovascular disease (CVD), in a large population (n:250) of patients with hypothalamic-pituitary disease. We then prospectively screened 90 such patients for the following CVD risk factors: obesity, diabetes mellitus, smoking...

Due to the infrequency of pituitary apoplexy, there are no robust evidence-based guidelines for optimum care of these patients. The key controversy surrounds the role of acute neurosurgical intervention. Over recent years we have adopted a relatively conservative approach and the aim of this study was to determine whether this 'non-intervention' affected long-term outcome in a recent cohort of patients. 19 patients (8 female) presented between 1994-2001. Mean age at diagnosis ...

Malignant intra ovarian tumor secreting glucocorticoïds is extremely rare (<5 cases reported in the world). Our aim is to report the first case observed in our practice. We also try to relate different mechanisms which are discussed in literature to explain intra ovarian position of adrenocortical tissue.Case report: KM, 34 years, female, mother of two children, came for lower limbs edema which began one month after last delivery. Clinical exam ...

Introduction: Nowadays, thyroid Ultrasound (US) is a reference exam and the best way for detection, diagnosis and monitoring of thyroid nodules suspect of malignancy. It allows selection of suspicious thyroid nodules for malignancy.Our aim was to assess contribution of this exam using the TI-RADS score in order to establish the correlation with cytological results.Materials and methods: A prospective study of 395 pati...

Introduction: Nowadays, thyroid Ultrasound (US) is a reference exam and the best way for detection, diagnosis and monitoring of thyroid nodules suspect of malignancy. It allows selection of suspicious thyroid nodules for malignancy.Our aim was to assess contribution of this exam using the TI-RADS score in order to establish the correlation with cytological results.Materials and methods: A prospective study of 395 pati...

Introduction: Aminoterminal pro B type natriuretic peptide (NT-pro BNP) is the inactive degradation product of pro BNP. Thyroid diseases are known to have effect on NT-pro BNP levels. In this study, we aimed to determine possible changes in NT-pro BNP levels in patients with thyroid dysfunctions.Material and method: Fifteen patients with hyperthyroidism, 8 with subclinical hyperthyroidism, 12 with hypothyroidism, 15 with subclinical hypothyroidism and 35...